Risks and Benefits of Semaglutide for Weight Loss:

Benefits:

• Helps regulate appetite and reduce cravings - leading to steady, sustainable weight loss

• Supports improved metabolic health

• Non-surgical and easy to administer with weekly injections

• Participants in the STEP trial lost ~15% of their body weight when using semaglutide, compared to placebo groups (2%) when combined with diet and exercise.

How they Work:

• Semaglutide is a GLP-1 receptor agonist that mimics a natural hormone involved in regulating appetite and digestion.

• Promotes feelings of fullness by interacting with the brain’s appetite regulation centers.

• Slows gastric emptying, which can help prolong the sensation of fullness.

• Helps reduce appetite and support weight management by influencing hunger signals in the body.

Potential Risks & Side Effects:

• Some patients may experience nausea, digestive discomfort, or fatigue, especially during the first few weeks

• Not recommended for individuals with a history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 (MEN2)

• Should not be used during pregnancy or while trying to conceive

Who Can and Cannot Use Semaglutide?

You May Be a Good Candidate If:

• You have a BMI of 27 or higher with weight-related health concerns, or a BMI of 30 or higher

• You have struggled with weight loss through diet and exercise alone

• You are looking for a clinician-supervised approach to weight loss

You Should Not Use Semaglutide If:

• You have known Type 1 Diabetes, or currently being treated for Type 2 diabetes by another provider

• You have a personal or family history of medullary thyroid cancer (MTC) or MEN2

• You are pregnant, nursing, or actively trying to conceive

• You have a known allergy to semaglutide or any of its ingredients

• You have severe gastrointestinal disease or a history of pancreatitis (discuss this with the provider)

Semaglutide is not intended as a standalone solution for weight loss. It should be used as part of a comprehensive weight management plan, which includes diet, exercise, and professional guidance. Individual results may vary.