Risks and Benefits of Semaglutide for Weight Loss:
Benefits:
• Helps regulate appetite and reduce cravings - leading to steady, sustainable weight loss
• Supports improved metabolic health
• Non-surgical and easy to administer with weekly injections
• Participants in the STEP trial lost ~15% of their body weight when using semaglutide, compared to placebo groups (2%) when combined with diet and exercise.
How they Work:
• Semaglutide is a GLP-1 receptor agonist that mimics a natural hormone involved in regulating appetite and digestion.
• Promotes feelings of fullness by interacting with the brain’s appetite regulation centers.
• Slows gastric emptying, which can help prolong the sensation of fullness.
• Helps reduce appetite and support weight management by influencing hunger signals in the body.
Potential Risks & Side Effects:
• Some patients may experience nausea, digestive discomfort, or fatigue, especially during the first few weeks
• Not recommended for individuals with a history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 (MEN2)
• Should not be used during pregnancy or while trying to conceive
Who Can and Cannot Use Semaglutide?
You May Be a Good Candidate If:
• You have a BMI of 27 or higher with weight-related health concerns, or a BMI of 30 or higher
• You have struggled with weight loss through diet and exercise alone
• You are looking for a clinician-supervised approach to weight loss
You Should Not Use Semaglutide If:
• You have known Type 1 Diabetes, or currently being treated for Type 2 diabetes by another provider
• You have a personal or family history of medullary thyroid cancer (MTC) or MEN2
• You are pregnant, nursing, or actively trying to conceive
• You have a known allergy to semaglutide or any of its ingredients
• You have severe gastrointestinal disease or a history of pancreatitis (discuss this with the provider)
Semaglutide is not intended as a standalone solution for weight loss. It should be used as part of a comprehensive weight management plan, which includes diet, exercise, and professional guidance. Individual results may vary.